Anti-NOD2

Anti-NOD2 Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest cross-reactivity with NOD2 with Human based on 100% homology with the immunizing sequence. Cross-reactivity with NOD2 from other sources has not been determined. Antibody has no cross reaction with NOD1. NOD2 Antibody detects human NOD2. Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappaB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease. Anti-NOD2 antibodies are ideal for investigators involved in NFkappaB and Cytokines and Growth factor research.