Anti-NME5

The NME5 gene encodes a 212-amino acid polypeptide with homology to the NDP kinases. Northern blot analysis detected abundant expression of a 1.1-kb mRNA in testis. In situ hybridization to testis revealed NME5 mRNA in the seminiferous tubules in a pattern consistent with stage-specific expression in germinal cells during spermatogenesis. Protein function: Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. [The UniProt Consortium]