Anti-NLRP2 / NALP2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. NLRP2 antibody detects NACHT, LRR, and PYD domains-containing protein 2, an intracellular innate immune sensor that regulates inflammasome signaling, apoptosis, and embryonic development. Encoded by the NLRP2 gene on chromosome 19q13.42, this protein belongs to the NOD-like receptor (NLR) family characterized by an N-terminal pyrin domain (PYD), a central NACHT domain responsible for oligomerization, and C-terminal leucine-rich repeats (LRRs) involved in ligand sensing. NLRP2 acts as a cytoplasmic pattern-recognition receptor that modulates NF-kB and caspase-1 activation pathways, thereby influencing inflammatory cytokine production.NLRP2 expression is found in oocytes, testis, brain, and immune tissues. In germ cells and early embryos, NLRP2 contributes to epigenetic regulation of imprinted gene expression and maintenance of zygotic genome integrity. Mutations in NLRP2 are associated with imprinting disorders such as Beckwith-Wiedemann and multilocus imprinting disturbances. In immune cells, NLRP2 serves as a negative regulator of inflammasome activity, limiting excessive IL-1beta secretion and preventing aberrant inflammation. Its dual role in reproduction and immunity underscores its importance in maintaining both developmental and immune homeostasis.The NLRP2 antibody is used in immunology, developmental, and reproductive research to study inflammasome signaling and maternal effect gene function. Western blot analysis reveals a 115 kilodalton band, while immunofluorescence shows cytoplasmic and perinuclear staining consistent with inflammasome localization. The antibody helps characterize NLRP2's interactions with ASC and caspase-1 in immune signaling complexes. In reproductive studies, it assists in analyzing NLRP2's role in zygotic reprogramming and early embryonic gene activation. Loss or mutation of NLRP2 disrupts normal embryogenesis and can cause early developmental arrest.In addition to its developmental and immunological roles, NLRP2 may contribute to cancer and neurological disease by modulating inflammation and apoptosis. Reduced expression is observed in gliomas and certain carcinomas, while overactivation of inflammasome signaling has been linked to neuroinflammation and tissue injury. The NLRP2 antibody thus supports research across multiple fields, from innate immunity to epigenetic regulation. NSJ Bioreagents provides this antibody validated for its applications to ensure specificity in both human and model systems.