Anti-NLGN2

Anti-NLGN2 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist, this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family. Protein function: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. [The UniProt Consortium]