Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
366973.100 | 100 µl | - | - |
3 - 19 business days* |
796.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Ninein (UniProt Q61043, also known as Glycogen synthase kinase 3 beta-interacting protein,... more
Product information "Anti-Ninein (Glycogen Synthase Kinase 3 beta-interacting Protein, GSK3B-interacting Protein)"
Ninein (UniProt Q61043, also known as Glycogen synthase kinase 3 beta-interacting protein, GSK3B-interacting protein) is encoded by the Nin (also known as Kiaa1565) gene (Gene ID 18080) in murine species. Ninein is a microtubule (MT) minus-end-binding protein that helps anchor the MTs to the centrosome. Ninein is also found in noncentrosomal locations in association with the minus-end of noncentrosomal MTs present in polarized cells. Ninein is essential for the self-renewal and maintenance of apical progenitors (APs) in developing mouse neocortex by anchoring of MTs to the centrosome, while only noncentrosomal ninein is seen in cortical neurons where it is localized to the axons and the somatodendritic compartment. Centrosome-associated ninein plays an important role in stabilizing the radial MT asters, while noncentrosomal ninein plays an MT-stabilizing role in the axons of neurons. Ninein is a downstream target of the transcription factor Sip1 involved in CNS development. Re-expression of ninein in Sip1-deficient neurons or overexpressing ninein in wild-type neurons significantly increases their resistance to MT depolymerization. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry, Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:250 detects cytoplasmic ninein immunoreactivity in human brain and spleen tissue sections. , Immunocytochemistry: 1:500 detects cytoplasmic and centrosome ninein immunoreactivity in 0.1 Triton X-100 extracted and 4% paraformaldehyde-fixed HEK293T cells, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Ninein |
Supplier: | United States Biological |
Supplier-Nr: | 366973 |
Properties
Application: | ICC, IF, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant protein fragment corresponding to mouse ninein at the region between EF-hands 2&5, fused to His-Tag. |
Format: | Serum |
Database Information
KEGG ID : | K16476 | Matching products |
UniProt ID : | Q61043 | Matching products |
Gene ID | GeneID 18080 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed