Anti-NGRN

function:May be involved in neuronal differentiation.,induction:Highly up-regulated in neuroblastostoma cells by RA treatment inducing neurite outgrowth.,similarity:Belongs to the neugrin family.,tissue specificity:Expressed at high levels in heart, brain and skeletal muscle. In brain, mainly expressed in neurons rather than glial cells., Protein function: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Nucleus . Secreted . Mitochondrion membrane .