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The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit... more
Product information "Anti-NFKBIB"
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene. Protein function: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. [The UniProt Consortium]
Keywords: | Anti-IKBB, Anti-IkB-B, Anti-TRIP-9, Anti-NFKBIB, Anti-IkB-beta, Anti-IkappaBbeta, Anti-NF-kappa-BIB, Anti-I-kappa-B-beta, Anti-TR-interacting protein 9, Anti-NF-kappa-B inhibitor beta, Anti-Thyroid receptor-interacting protein 9, NFKBIB Polyclonal Antibod |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-70167 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse IKBß |
Database Information
KEGG ID : | K02581 | Matching products |
UniProt ID : | Q15653 | Matching products |
Gene ID | GeneID 4793 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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