Anti-NETO2 / Neuropilin and tolloid-like protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. NETO2 antibody detects Neuropilin and tolloid-like protein 2, a transmembrane glycoprotein that functions as an auxiliary subunit of kainate-type glutamate receptors (KARs), modulating receptor kinetics and synaptic transmission. NETO2 is involved in regulating excitatory neurotransmission, synaptic plasticity, and neuronal communication. The NETO2 antibody is widely used in neurobiology, electrophysiology, and developmental studies to explore receptor modulation and synaptic organization.NETO2 is encoded by the NETO2 gene located on human chromosome 16q12.1. The protein is approximately 525 amino acids in length and contains two extracellular CUB domains, a low-density lipoprotein receptor-like domain, a transmembrane segment, and a short cytoplasmic tail. It localizes to the postsynaptic membrane in neurons, where it interacts with KAR subunits such as GluK1 and GluK2 to regulate receptor assembly and surface expression.The NETO2 antibody detects a 62 kilodalton protein by western blot and reveals punctate synaptic staining under immunofluorescence microscopy. NETO2 enhances the functional diversity of KARs by altering desensitization rates and gating properties, shaping excitatory signaling in neural circuits. It is required for normal synaptic strength and contributes to processes like long-term potentiation and synaptic scaling.Loss of NETO2 leads to impaired excitatory transmission, altered neuronal connectivity, and behavioral abnormalities, including deficits in learning and memory. NETO2 is expressed in multiple brain regions, including the hippocampus and cortex, and its dysregulation has been implicated in autism spectrum disorders and schizophrenia. Outside the brain, NETO2 may participate in neuronal migration and development of sensory pathways.Because NETO2 serves as a critical regulator of excitatory synapse function, it provides valuable insight into glutamate receptor modulation and synaptic homeostasis. NSJ Bioreagents provides a validated NETO2 antibody optimized for its applications, supporting research into excitatory neurotransmission, receptor function, and neurological disorders.