Anti-NEK7 / NIMA related kinase 7

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. NEK7 antibody detects NIMA related kinase 7, encoded by the NEK7 gene. NIMA related kinase 7 is a serine/threonine protein kinase belonging to the NIMA related kinase family, which plays important roles in mitotic progression, spindle assembly, and cytokinesis. NEK7 antibody provides researchers with a specific reagent for studying cell cycle regulation, mitotic control, and disease processes associated with abnormal kinase activity.NIMA related kinase 7 is expressed in proliferating tissues and localizes to the centrosome during mitosis. Research using NEK7 antibody has shown that it regulates microtubule organization, spindle formation, and chromosome segregation. By phosphorylating structural and regulatory proteins, NEK7 ensures orderly mitotic progression and completion of cytokinesis.Studies with NEK7 antibody have also revealed a role in inflammasome activation. NEK7 interacts with NLRP3 and is essential for assembly of the NLRP3 inflammasome, which mediates caspase-1 activation and interleukin-1 beta processing. This discovery links NEK7 to innate immunity and inflammation, broadening its functional scope beyond mitosis.Dysregulation of NEK7 has been implicated in cancer and inflammatory disease. Research using NEK7 antibody has shown that overexpression promotes proliferation and survival in certain cancers, while loss-of-function impairs mitotic fidelity and contributes to chromosomal instability. In immune contexts, defective NEK7 regulation disrupts inflammasome activity, contributing to autoinflammatory syndromes.NEK7 antibody is commonly used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies kinase levels in proliferative tissues, immunohistochemistry highlights centrosomal and tumor expression, and immunofluorescence reveals dynamic localization during mitosis. These applications make NEK7 antibody indispensable for cell cycle and inflammation research.By providing validated NEK7 antibody reagents, NSJ Bioreagents supports studies into mitosis, innate immunity, and cancer biology. Detection of NIMA related kinase 7 provides researchers with insight into how kinases regulate both cell division and immune signaling.