Anti-NEDD4L

Anti-NEDD4L
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-514A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-514A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-514A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2... more
Product information "Anti-NEDD4L"
Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). [The UniProt Consortium]
Keywords: Anti-NEDD4L, Anti-Nedd4-2, Anti-NEDD4.2, Anti-KIAA0439, EC=2.3.2.26, Anti-E3 ubiquitin-protein ligase NEDD4-like, Anti-HECT-type E3 ubiquitin transferase NED4L
Supplier: Bethyl Laboratories
Supplier-Nr: A302-514A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-514A-T maps to a region between residue 425 and 475 of human neural precursor cell expressed, developmentally down-regulated 4-like using the numbering given in entry NP_001138439.1 (GeneID 23327).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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