Anti-NDUFS1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1) is a vital component of mitochondrial complex I, the largest enzyme of the respiratory chain. This nuclear-encoded protein serves as a core subunit of the iron-sulfur protein (ISP) fraction, where it plays an essential role in electron transfer from NADH to ubiquinone. By facilitating the first step in oxidative phosphorylation, NDUFS1 directly contributes to ATP production, making it crucial for cellular energy metabolism. Research utilizing an NDUFS1 antibody has highlighted the importance of this protein in maintaining mitochondrial integrity and function. Mutations in the NDUFS1 gene are associated with mitochondrial complex I deficiencies, a leading cause of numerous mitochondrial disorders. These conditions often present with neurodegenerative features, metabolic dysfunction, and progressive encephalopathy. Studies employing an NDUFS1 antibody have provided valuable insights into how loss of function impacts respiratory chain activity and contributes to disease pathology. Beyond inherited disorders, dysregulation of NDUFS1 has been implicated in aging, neurodegenerative diseases such as Parkinson's, and ischemic injury. Because mitochondrial dysfunction is a common hallmark of these conditions, NDUFS1 remains an attractive marker for evaluating mitochondrial activity in research models. Use of an NDUFS1 antibody allows for detailed detection in techniques including western blot, immunohistochemistry, and immunofluorescence. NSJ Bioreagents provides high-quality NDUFS1 antibody reagents for worldwide researchers investigating mitochondrial biology. These reagents enable the exploration of NDUFS1's role in energy production, cellular stress responses, and disease progression.