Anti-NDP / Norrin

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG40484.50	50 µg		-	-	6 - 14 business days*		625.00€

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Protein function: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor.... more

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Product information "Anti-NDP / Norrin"

Protein function: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. [The UniProt Consortium]

Keywords:	Anti-NDP, Anti-EVR2, Anti-Norrin, Anti-Norrie disease protein, Anti-X-linked exudative vitreoretinopathy 2 protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG40484

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Synthetic peptide around 18 aa from (N-terminus) of Human Norrin
Format:	Antigen Affinity Purified