Anti-NCDN / Neurochondrin

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. NCDN antibody recognizes Neurochondrin, a cytoplasmic protein that modulates neuronal differentiation, receptor signaling, and synaptic plasticity. Neurochondrin is widely expressed in the central nervous system, including the hippocampus, cerebellum, and cerebral cortex, where it influences long-term synaptic potentiation and memory formation. The protein functions as a negative regulator of metabotropic glutamate receptor 5 (mGluR5) signaling by interacting with G-protein coupled receptor complexes, thereby controlling calcium homeostasis and dendritic spine development. During neural differentiation, Neurochondrin promotes neurite outgrowth and cytoskeletal organization, making it a key factor in neuronal morphogenesis.Neurochondrin, encoded by the NCDN gene on chromosome 12q13.3, is approximately 79 kilodaltons in size and highly conserved among vertebrates. It is enriched in postmitotic neurons and functions as a scaffold linking cell surface receptors with intracellular signaling cascades. The protein associates with calmodulin and modulates calcium-dependent processes critical for neuronal excitability. In animal models, loss of NCDN expression disrupts spatial learning and synaptic signaling, underscoring its role in cognitive function. Furthermore, mutations or altered expression of NCDN have been linked to neurodevelopmental disorders and schizophrenia, highlighting its importance in brain health and disease.The NCDN antibody is used to study neuronal signaling and synaptic regulation in both developmental and disease contexts. In research applications, it detects Neurochondrin by western blot, immunocytochemistry, and immunohistochemistry. The antibody identifies distinct cytoplasmic localization in neurons, particularly within dendritic arbors, consistent with its role in synaptic modulation. Beyond the brain, Neurochondrin expression has been detected in cardiac and endocrine tissues, suggesting additional regulatory functions outside the nervous system. Proteomic studies have also linked NCDN to cytoskeletal organization and intracellular trafficking networks.Through its interactions with signaling proteins such as CaMKII and GRM5, Neurochondrin integrates receptor activation with downstream pathways influencing synaptic plasticity and learning. Its modulation of calcium signaling provides a mechanistic link between neurotransmission and neuronal adaptation. Because of these diverse regulatory roles, the NCDN antibody is a valuable reagent for exploring molecular mechanisms underlying cognition, synaptic remodeling, and psychiatric disorders. NSJ Bioreagents offers this antibody validated for high specificity and sensitivity in neural tissue applications.