Anti-NANS / Sialic acid synthase

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The NANS antibody targets Sialic acid synthase, a cytosolic enzyme encoded by the NANS gene that catalyzes the formation of N-acetylneuraminic acid (Neu5Ac), the most abundant sialic acid in mammals. Sialic acids are terminal sugars found on glycoproteins and glycolipids, playing vital roles in cell-cell communication, pathogen recognition, and immune modulation. Sialic acid synthase converts N-acetylmannosamine-6-phosphate and phosphoenolpyruvate into N-acetylneuraminic acid-9-phosphate, which is later dephosphorylated to yield Neu5Ac. The NANS antibody enables precise detection of this enzyme, supporting research into glycosylation pathways, metabolic regulation, and genetic disease mechanisms.Sialic acid synthase is widely expressed in tissues that actively produce glycoproteins, including liver, brain, and immune cells. The enzyme's activity is essential for the biosynthesis of sialylated glycoconjugates, which are critical for neuronal development and immune recognition. The NANS antibody allows researchers to monitor NANS expression levels and subcellular localization, facilitating studies that explore how sialic acid metabolism supports neural growth and synaptic function. In the developing brain, altered sialylation affects axonal targeting and synaptic plasticity, making this enzyme an important target in neurobiology.Mutations in NANS cause sialic acid synthase deficiency, a rare autosomal recessive disorder characterized by skeletal dysplasia, developmental delay, and metabolic abnormalities. These mutations impair enzyme activity, leading to reduced sialic acid production and accumulation of precursors such as N-acetylmannosamine. The NANS antibody is an essential reagent for diagnosing and studying this deficiency, allowing direct measurement of protein levels and identification of loss-of-function variants. By detecting Sialic acid synthase in cellular and tissue models, researchers can examine how disrupted glycan biosynthesis contributes to disease phenotypes.Beyond human pathology, Sialic acid synthase plays roles in host-pathogen interactions. Many viruses and bacteria exploit sialic acid residues for attachment and immune evasion. The NANS antibody helps elucidate how modulation of sialic acid synthesis influences infection susceptibility and immune responses. Additionally, this enzyme's regulation under hypoxia and stress conditions highlights its connection to energy metabolism and cellular adaptation.The NANS antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry. It yields strong cytoplasmic staining consistent with Sialic acid synthase localization. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for consistent results across applications. By enabling the study of glycan biosynthesis and metabolic signaling, the NANS antibody supports research in developmental biology, glycobiology, and metabolic disorders, helping clarify the essential role of sialic acid synthesis in human physiology.