Anti-NAA80 / N-acetyltransferase 80 / NAT6 / FUS2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. NAA80 antibody detects N-acetyltransferase 80, also known as NAT6 or FUS2, encoded by the NAA80 gene. N-acetyltransferase 80 is an enzyme responsible for acetylating the N-terminus of actin, making it unique among N-acetyltransferases in directly modifying one of the most abundant and essential cytoskeletal proteins. NAA80 antibody provides researchers with a specialized reagent for studying actin regulation, cytoskeletal organization, and post-translational modification.N-acetyltransferase 80 belongs to the GNAT (GCN5-related N-acetyltransferase) superfamily. Research using NAA80 antibody has shown that its primary substrate is actin, which requires acetylation of its N-terminal methionine for proper filament assembly and function. This modification influences actin polymerization dynamics, cell motility, and stability of actin filaments, positioning NAA80 as a critical regulator of cytoskeletal behavior.Studies with NAA80 antibody have revealed that deletion or loss of NAA80 activity results in defects in actin filament organization, impaired migration, and altered cell morphology. These findings highlight its unique and non-redundant role among acetyltransferases. Furthermore, its specificity toward actin suggests a tightly controlled regulatory mechanism essential for cell function.Dysregulation of NAA80 has been associated with human disease. Research using NAA80 antibody has shown that genetic mutations can lead to developmental delay, intellectual disability, and impaired muscle function. These phenotypes result from widespread disruption of actin-dependent processes, including vesicle trafficking, adhesion, and signal transduction. In cancer research, altered expression of NAA80 has been observed in tumors, linking cytoskeletal remodeling to oncogenesis.NAA80 antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies enzyme levels across tissues, immunohistochemistry highlights expression in developing muscle and neurons, and immunofluorescence reveals subcellular localization within the cytoplasm. These applications make NAA80 antibody valuable for cytoskeletal and post-translational modification research.By supplying validated NAA80 antibody reagents, NSJ Bioreagents supports studies into actin acetylation, cytoskeletal dynamics, and disease. Detection of N-acetyltransferase 80 provides researchers with insight into how post-translational regulation of actin influences cell biology and pathology.