Anti-N Cadherin [R49-7X-7] Monoclonal Antibody, unconjugated, detector (PBS Only)

N Cadherin Monoclonal Antibody, unconjugated, detector (PBS Only) from Assay Genie is a high quality antibody for research use only. Protein Function: Calcium-dependent cell adhesion protein, preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell (PubMed:11433297, PubMed:17988630, PubMed:25253890, PubMed:2762814, PubMed:9655503). Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463). Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (PubMed:26750727). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density [The Uniprot Consortium]