Anti-Myosin Heavy Chain (developmental), clone RNMY2/9D2 (monoclonal) [Mouse]

Note that this antibody recognises a myosin heavy chain (MHC) present during the embryonic and neonatal period in the development of skeletal muscle. The same MHC occurs during regeneration of muscle fibres. Also reacts with rat myosin developmental type heavy chain. Myosin is a contractile muscle specific protein composed of two heavy and four light chains. The myosin heavy chain has many isoforms which are specific for different muscles or fibre types, some of which are developmentally regulated. The range of myosin heavy chain antibodies may prove useful for investigating development of intrafusal and extrafusal muscle fibres and the course of muscle fibre regeneration. At the ultrastructural level, antibodies can reveal architectural details of the myofilament and sites of new myosin integration. Protein function: Muscle contraction. [The UniProt Consortium]