Anti-Myogenin, clone F12B

Anti-Myogenin, clone F12B
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG20575.50 50 µg - -

6 - 14 business days*

640.00€
 
Protein function: Acts as a transcriptional activator that promotes transcription of... more
Product information "Anti-Myogenin, clone F12B"
Protein function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth, phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts. [The UniProt Consortium]
Keywords: Anti-Myog, Anti-Myogenin
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG20575

Properties

Application: IHC (paraffin), ICC, IF, IP, WB
Antibody Type: Monoclonal
Clone: F12B
Conjugate: No
Host: Mouse
Species reactivity: human, mouse, rat
Immunogen: Recombinant protein around aa. 30-224 of Rat myogenin and Mouse myeloma NS1 cells
MW: 34 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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