Anti-MyD88

0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. MYD88 (myeloid differentiation primary response 88) is an essential signal transducer in the IL-1R and Toll-like receptor signaling pathways which regulate activation of numerous proinflammatory genes. Activated TLR signaling via MYD88 ultimately leads to IKK activation, IkB degradation and NF-kB mediated signaling. Protein function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. [The UniProt Consortium]