Anti-MYBBP1A / Myb-binding protein 1A

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MYBBP1A antibody detects Myb-binding protein 1A, a nucleolar transcriptional regulator that modulates gene expression, chromatin structure, and cell cycle progression. Encoded by the MYBBP1A gene on chromosome 17p13.3, this large nuclear protein was originally identified through its interaction with the Myb oncoprotein, but it also binds multiple transcription factors including p53, NF?B, and STAT3. MYBBP1A contains several acidic and coiled-coil domains that facilitate protein-protein interactions and nucleolar localization sequences that target it to the nucleolus under normal growth conditions. It functions as both a transcriptional coactivator and corepressor, integrating stress responses with cell cycle control.MYBBP1A plays a key role in ribosome biogenesis and nucleolar stress signaling. Upon cellular stress or energy depletion, MYBBP1A translocates from the nucleolus to the nucleoplasm, where it enhances p53 acetylation and activation, promoting cell cycle arrest and apoptosis. It also suppresses c-Myb-driven transcription to prevent uncontrolled proliferation. Through these mechanisms, MYBBP1A acts as a tumor suppressor and regulator of growth arrest. Depletion of MYBBP1A leads to impaired rRNA processing and increased genomic instability. Dysregulation of its expression has been reported in renal carcinoma, hepatocellular carcinoma, and hematologic malignancies.The MYBBP1A antibody is used in cancer biology and transcriptional regulation studies to detect Myb-binding protein 1A localization and abundance. Western blot analysis typically identifies a ~150 kilodalton band, while immunofluorescence shows predominant nucleolar staining with redistribution upon stress. Because MYBBP1A interacts with both histone-modifying enzymes and transcriptional machinery, it is a critical factor for understanding nucleolar function and epigenetic regulation. The antibody is effective in chromatin immunoprecipitation, immunohistochemistry, and nuclear fractionation assays. The MYBBP1A antibody therefore supports research on tumor suppression, transcriptional control, and nucleolar biology. NSJ Bioreagents provides this reagent validated for high specificity and reproducibility across applications.