Protein function: May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. [The UniProt Consortium]
Anti-P160, Anti-MYBBP1A, Anti-Myb-binding protein 1A
synthetic peptide. The epitope recognized by IHC-00307 maps to a region between residue 450 and 500 of human MYB binding protein (P160) 1a using the numbering given in entry NP_055335.1 (GeneID 10514).