Anti-MUC1 (EMA), clone SPM492

Anti-MUC1 (EMA), clone SPM492
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V2727-20UG 20 µg - -

3 - 10 business days*

332.00€
NSJ-V2727-100UG 100 µg - -

3 - 10 business days*

752.00€
 
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This mAb reacts with... more
Product information "Anti-MUC1 (EMA), clone SPM492"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. This mAb reacts with MUC1/Mucin-1/Epithelial Marker Antigen/EMA. The dominant epitope of this mAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver. Protein function: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. [The UniProt Consortium]
Keywords: Anti-PUM, Anti-MUC1, MUC1 Antibody (EMA)
Supplier: NSJ Bioreagents
Supplier-Nr: V2727

Properties

Application: ELISA, FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM492
Conjugate: No
Host: Mouse
Species reactivity: human, mouse
Immunogen: Breast Cancer Cell line ZR75-1
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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