Anti-MST1,2/STK3,4 (IHC)

Anti-MST1,2/STK3,4 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00432-T 10 µl (5+ slides) -

6 - 10 business days*

IHC-00432 100 µl (50+ slides) -

6 - 10 business days*

Protein function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage,... more
Product information "Anti-MST1,2/STK3,4 (IHC)"
Protein function: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1. Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. [The UniProt Consortium]
Keywords: Anti-KRS1, Anti-STK3, EC=
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00432


Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rat, Zebrafish, X. Laevis, X. Tropicalis, Turkey, Bovine, Horse, Rabbit, Guinea Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Nile Tilapia, White-tufted-ear Marmoset, Spotted Green Pufferfish)
Immunogen: synthetic peptide. The epitope recognized byIHC-00432 maps to the C-terminus of human Mammalian Sterile 20-like 2 (Serine/Threonine Kinase 3) using the numbering given in Swiss Prot entry Q13188 (GeneID 6788). The epitope is highly conserved with MST1(STK4).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Our products are for laboratory research use only: Not for administration to humans!
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