Anti-MSL2 / Male-specific lethal-2 homolog

0.5mg/ml if reconstituted with 0.2ml sterile DI water. MSL2 (MSL Complex Subunit 2) is a protein coding gene located on human chromosome 3q22.3. MSL2 is also known as MSL-2, MSL2L1 and RNF184. The human MSL2 gene encodes a 62541 Da protein containing 577 amino acids. The MSL2 protein is ubiquitously expressed in bone marrow, lymph node and other tissues. Among its related pathways are Chromatin organization and Chromatin Regulation / Acetylation. MSL2 is related to ligase activity. MSL2 is associated with some diseases, such as Atrial Septal Defect 3. Protein function: Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. [The UniProt Consortium]