Anti-MSI2 / Musashi RNA-binding protein 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MSI2 antibody detects Musashi RNA-binding protein 2, an evolutionarily conserved RNA-binding protein that regulates mRNA translation and stem cell maintenance. MSI2 belongs to the Musashi family, which controls post-transcriptional gene expression during development and cancer progression. The MSI2 antibody is widely used in stem cell biology, leukemia research, and studies of neural differentiation to examine mRNA regulation and self-renewal mechanisms.MSI2 is encoded by the MSI2 gene located on human chromosome 17q23.2. The protein is approximately 38 kilodaltons and contains two RNA recognition motifs (RRMs) at the N-terminus that specifically bind to target mRNAs containing UAG motifs in their 3' untranslated regions. Through this interaction, MSI2 represses translation of transcripts involved in differentiation while enhancing those promoting proliferation and stemness. MSI2 expression is particularly high in hematopoietic stem cells and neural progenitors.The MSI2 antibody detects a 38 kilodalton band by western blot and shows cytoplasmic and perinuclear staining in stem cell populations and tumor cells. MSI2 regulates asymmetric cell division and maintains an undifferentiated state by antagonizing translational repressors such as PABP and interacting with the translational initiation machinery. In hematopoiesis, MSI2 cooperates with HOXA9 and MYC signaling to promote leukemic transformation. Overexpression correlates with poor prognosis in acute myeloid leukemia, breast cancer, and colorectal carcinoma.In the nervous system, MSI2 modulates neurogenesis by controlling translation of key developmental regulators such as NUMB and REST. Loss of MSI2 leads to premature differentiation and reduced progenitor proliferation. Its function is tightly regulated by phosphorylation and interaction with signaling pathways including Notch and mTOR.Because of its dual role in maintaining stemness and driving oncogenesis, MSI2 serves as a key marker and therapeutic target in cancer stem cell biology. NSJ Bioreagents provides a validated MSI2 antibody optimized for its applications, supporting detailed research into translational control, stem cell regulation, and tumor initiation.