Anti-Mre11

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-998A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A303-998A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A303-998A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Component of the MRN complex, which plays a central role in double-strand break... more
Product information "Anti-Mre11"
Protein function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). [The UniProt Consortium]
Keywords: Anti-HNGS1, Anti-MRE11 homolog A, Anti-MRE11 homolog 1, Anti-Meiotic recombination 11 homolog A, Anti-Meiotic recombination 11 homolog 1, Anti-Double-strand break repair protein MRE11, Anti-Double-strand break repair protein MRE11A
Supplier: Bethyl Laboratories
Supplier-Nr: A303-998A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Rabbit, Rhesus Monkey, Gorilla, Chimpanzee, Crab-eating Macaque, Northern White-cheeked Gibbon, African Rice, Rice, Small-eared Galago, Paenibacillus Alvei, Marine Diatom_159749)
Immunogen: synthetic peptide. The epitope recognized by A303-998A-T maps to a region between residue 658 to 708 of human Meiotic Recombination 11 using the numbering given in entry NP_005582.1 (GeneID 4361).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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