Anti-MPXV H3L (9E12)

Monkeypox is a zoonotic disease caused by monkeypox virus (MPXV), which is a member of orthopoxvirus genus. A30L protein is required for the association of electron-dense, granular, proteinaceous material with the concave surfaces of crescent membranes, an early step in viral morphogenesis. The H3L protein can be attached to the IMV membrane by its C-terminal hydrophobic structure and bind to HS on the cell surface, promoting viral entry and the H3L protein is a target of cellular immune responses, and the protein exhibits at least two identified human leucocyte antigen (HLA) class I-restricted T-cell epitopes which can elicit robust IFN-gamma response. The H3L protein is one of the key targets for MPXV vaccine design.