Anti-MPO / Myeloperoxidase, clone MSVA-692M

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. Myeloperoxidase (MPO) is a heme-containing peroxidase enzyme encoded by the MPO gene and predominantly expressed in neutrophils and other cells of the myeloid lineage. Myeloperoxidase Antibody for IHC / MPO Immunohistochemistry Antibody (clone MSVA-692M) enables visualization of MPO expression in formalin-fixed, paraffin-embedded tissue sections using immunohistochemistry. This approach allows researchers to identify MPO-positive myeloid cells within the histological architecture of normal tissues and tumors.MPO antibody, also referred to as Myeloperoxidase antibody or myeloid peroxidase antibody in the literature, detects an abundant cytoplasmic enzyme localized within the azurophilic granules of neutrophils and other granulocytic cells. Because of this restricted expression pattern, immunohistochemistry staining with Myeloperoxidase Antibody for IHC highlights granulocytes and related myeloid lineage cells in tissue sections. The staining pattern typically appears as granular cytoplasmic labeling corresponding to MPO-containing granules.Immunohistochemistry analysis with MPO antibodies is widely used in hematopathology and cancer research to identify cells of myeloid origin. MPO immunohistochemistry staining can distinguish neutrophil lineage cells and is frequently used to evaluate inflammatory infiltrates or characterize myeloid differentiation in tumor or hematologic specimens. Cytoplasmic MPO staining within granulocytes provides a clear histological marker of myeloid cell populations.Immunohistochemistry also allows investigators to examine MPO-positive cells within the context of tissue architecture. In normal tissues, MPO-positive granulocytes may be observed within bone marrow or circulating within blood-rich organs. In tumor samples or inflammatory tissues, immunohistochemistry staining may highlight infiltrating neutrophils or other MPO-expressing cells present within the tumor microenvironment.Myeloperoxidase Antibody for IHC (clone MSVA-692M) has been evaluated by immunohistochemistry across a wide range of normal and cancer tissues using tissue microarray analysis. The immunohistochemistry staining patterns observed with this antibody align with Myeloperoxidase / MPO expression data reported in the Human Protein Atlas, supporting its use for histological detection of MPO-expressing cells. This antibody therefore supports immunohistochemistry-based visualization of MPO-positive myeloid cells in tissue sections.