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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-F1115A.25 | 25 µg | - |
7 - 16 business days* |
42.00€
|
|||
E-AB-F1115A.100 | 100 µg | - |
7 - 16 business days* |
79.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-gammaRalpha chain. It is a... more
Product information "Anti-Mouse CD119, Purified conjugated, clone GR-20"
CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-gammaRalpha chain. It is a class II cytokine receptor family member that serves as a IFN-gamma-binding chain associated with the IFN-gamma beta chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-gamma initiates and regulates a variety of immune responses. Protein function: Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:2530582, PubMed:2532365, PubMed:2137461, PubMed:2531896, PubMed:2530216). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:19889125). STAT3 can also be activated in a similar manner although activation seems weaker (PubMed:15284232). IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (PubMed:15522878). [The UniProt Consortium]
Keywords: | Anti-Ifngr, Anti-CD119, Anti-IFN-gamma-R1, Anti-IFN-gamma-R-alpha, Anti-IFN-gamma receptor 1, Anti-Interferon gamma receptor 1, Anti-Interferon gamma receptor alpha-chain, Purified Anti-Mouse CD119 Antibody[GR-20] |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-F1115A |
Properties
Application: | FC, FC (membrane) |
Antibody Type: | Monoclonal |
Clone: | GR-20 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Database Information
KEGG ID : | K05132 | Matching products |
UniProt ID : | P15261 | Matching products |
Gene ID | GeneID 15979 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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