Anti-MMP-12 (C-Term) Rabbit Monoclonal Antibody (Clone RM381)

Matrix metalloproteinase-12 (MMP-12) is a zinc-dependent metalloproteinase and member of the MMP protein family, which has roles in extracellular matrix (ECM) degradation. It is composed of an N-terminal proenzyme domain, a catalytic domain that contains the zinc-binding motif, and a hemopexin-like C-terminal domain. MMP-12 is a secreted protease expressed by macrophages. It is activated by the loss of the N-terminal proenzyme domain, and this active enzyme is further processed to mature MMP-12 via loss of the C-terminal domain. Levels of MMP-12 are increased in sputum from patients with chronic obstructive pulmonary disease (COPD). Plasma levels of MMP-12 are increased and positively associated with atherosclerosis and adverse coronary events in patients with type 2 diabetes mellitus. Tumor levels of MMP-12 are positively correlated with tumor size and poor overall survival in patients with hepatocellular carcinoma. Cayman's MMP-12 (C-Term) Rabbit Monoclonal Antibody (Clone RM381) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Macrophage Elastase, Matrix Metalloproteinase-12, MME. Immunogen: Peptide from the C-terminal region of human MMP-12. Clone Designation: RM381. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) MMP-12.