Anti-MKK7

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-237A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A304-237A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A304-237A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP... more
Product information "Anti-MKK7"
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. [The UniProt Consortium]
Keywords: Anti-MEK 7, Anti-JNKK2, Anti-SAPKK4, Anti-JNKK 2, Anti-MAP2K7, Anti-MAPKK 7, Anti-SAPKK-4, EC=2.7.12.2, Anti-JNK kinase 2, Anti-SAPK kinase 4, Anti-MAPK/ERK kinase 7, Anti-MAP kinase kinase 7, Anti-JNK-activating kinase 2
Supplier: Bethyl Laboratories
Supplier-Nr: A304-237A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat)
Immunogen: synthetic peptide. The epitope recognized by A304-237A-T maps to a region between residue 1 to 50 of human Mitogen-Activated Protein Kinase Kinase 7 using the numbering given in entry NP_660186.1 (GeneID 5609).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow. more
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-MKK7"
Write a review
or to review a product.
Viewed