Anti-MFSD2A / Major facilitator superfamily domain-containing protein 2A

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MFSD2A antibody detects Major facilitator superfamily domain-containing protein 2A, a sodium-dependent lysophosphatidylcholine symporter that mediates the uptake of docosahexaenoic acid (DHA) into the brain and retina. MFSD2A plays a critical role in maintaining the blood-brain barrier (BBB) and enabling lipid transport across endothelial cells. The MFSD2A antibody is widely used in neuroscience, vascular biology, and metabolic research to investigate BBB integrity, lipid trafficking, and neurodevelopmental regulation.MFSD2A is encoded by the MFSD2A gene located on human chromosome 1p34.2. The protein belongs to the major facilitator superfamily of solute carriers and is approximately 530 amino acids in length, with 12 predicted transmembrane helices. MFSD2A localizes to the plasma membrane of endothelial cells lining brain capillaries, where it functions as a transporter for lysophosphatidylcholine-bound polyunsaturated fatty acids. Unlike most nutrient transporters at the BBB, MFSD2A is not energy-dependent but couples lipid import to sodium gradients.The MFSD2A antibody detects a 62 kilodalton band in western blot and demonstrates strong vascular endothelial staining in brain tissue and retina. In mouse models, deletion of MFSD2A results in severe microcephaly, neuronal loss, and impaired synaptic development due to reduced DHA delivery to the brain. In adults, MFSD2A maintains BBB tightness by suppressing vesicular transcytosis, ensuring selective permeability and protecting the central nervous system from toxins and immune cell infiltration.MFSD2A expression is regulated by pericytes and Wnt/beta-catenin signaling pathways, linking vascular maturation to lipid metabolism. Its dysfunction has been associated with neurodevelopmental disorders, cognitive impairment, and visual defects. In cancer research, MFSD2A acts as a metastasis suppressor by inhibiting vascular leakage and tumor cell extravasation, demonstrating a dual role in nutrient transport and vascular homeostasis.Beyond the nervous system, MFSD2A participates in lipid absorption in the placenta and peripheral vasculature. Because of its essential function in brain DHA uptake, MFSD2A is a promising target for therapeutic strategies aimed at enhancing neuroprotection and treating BBB disorders. NSJ Bioreagents provides a validated MFSD2A antibody optimized for western blot, immunohistochemistry, and confocal microscopy, supporting studies of lipid transport, barrier regulation, and neurovascular signaling.