Anti-METTL3/MT-A70

Anti-METTL3/MT-A70
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-568A-T 10 µl (10 µg) -

3 - 9 business days

125.00€
A301-568A 100 µl (100 µg) -

3 - 9 business days

430.00€
 
Protein function: The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that... more
Product information "Anti-METTL3/MT-A70"
Protein function: The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues of some RNAs and regulates the circadian clock, differentiation of embryonic stem cells and primary miRNA processing (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:27373337, PubMed:27281194, PubMed:9409616). In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (PubMed:27373337, PubMed:27281194). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs. M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). METTL3 also mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998). Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm (PubMed:27117702). Its overexpression in a number of cancer cells suggests that it may participate to cancer cell proliferation by promoting mRNA translation (PubMed:27117702). [The UniProt Consortium]
Keywords: Anti-MTA70, Anti-MT-A70, Anti-METTL3, Anti-hMETTL3, Anti-Methyltransferase-like protein 3, Anti-N6-adenosine-methyltransferase 70 kDa subunit
Supplier: Bethyl Laboratories
Supplier-Nr: A301-568A-T

Properties

Application: IP, IHC
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human (Expected: Mouse)
Immunogen: synthetic peptide. The epitope recognized by A301-568A-T maps to a region between residue 530 and 580 of human methyltransferase like 3 (N6-adenosine-methyltransferase 70 kDa subunit) using the numbering given in entry NP_062826.2 (GeneID 56339).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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