Anti-METTL11A / NRMT / NTMT1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The NTMT1 gene encodes an N-terminal methyltransferase (N-terminal RCC1 methyltransferase, NRMT1, METTL11A) for the RAN guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1). The enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200). Protein function: Distributive alpha-N-methyltransferase that methylates the N- terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]- Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. [The UniProt Consortium]