Anti-METTL1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA050450.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA050450.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Methyltransferase that mediates the formation of N(7)- methylguanine in a... more

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Product information "Anti-METTL1"

Protein function: Methyltransferase that mediates the formation of N(7)- methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:31031084). Internal N(7)-methylguanine methylation of mRNAs regulates translation (PubMed:31031084). Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083). Acts as a regulator of embryonic stem cell self-renewal and differentiation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 90% and to rat: 89%

Keywords:	Anti-tRNA(m7G46)-methyltransferase, Anti-Methyltransferase-like protein 1, Anti-mRNA (guanine-N(7)-)-methyltransferase, Anti-tRNA (guanine-N(7)-)-methyltransferase, Anti-miRNA (guanine-N(7)-)-methyltransferase
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA050450

Properties

Application:	ICC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: NQSHDDPKDK KEKRAQAQVE FADIGCGYGG LLVELSPLFP DTLILGLEIR VKVSDYVQDR IRALRAAPAG GFQ (ATA-APrEST89620)