Anti-mett-10

Make to order. Production time: 70-80 business days. Deliverables: 1. 200 µg antigen (used as positive control), 2. 1 ml pre-immune serum (used as negative control) , 3. Rabbit polyclonal antibody, antigen affinity purified. Quality Guarantee: 1. Antibody purity > 90% confirmed by SDS-PAGE, 2. Antibody titer > 1: 64,000 confirmed by ELISA, 3. WB positive with the immunogen protein (not applicable for synthetic peptide). Applications: ELISA, WB (positive for the recombinant immunogen protein/peptide). Buffer: Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Protein function: RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5) (PubMed:33930289). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence (PubMed:33930289). Plays a key role in S-adenosyl-L- methionine homeostasis: under rich-diet conditions, catalyzes N6- methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S- adenosylmethionine synthase (PubMed:33930289). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA) (PubMed:33930289). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development (PubMed:19596901, PubMed:19752194). Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate (PubMed:19596901, PubMed:19752194). Plays a role in the development of the vulva, somatic gonad and embryo (PubMed:19596901). [The UniProt Consortium]