Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-614A-T 20 µl (2 blots) -

3 - 9 business days*

A303-614A-M 100 µl (10 blots) -

3 - 9 business days*

A303-614A 100 µl (100 µg) -

3 - 9 business days*

Protein function: Protein derived from the fusion of a methylase with the transposase of an... more
Product information "Anti-Metnase"
Protein function: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). [The UniProt Consortium]
Keywords: Anti-Metnase, Anti-Transposon Hsmar1 transposase, Anti-Histone-lysine N-methyltransferase, Anti-Histone-lysine N-methyltransferase SETMAR, Anti-SET domain and mariner transposase fusion protein
Supplier: Bethyl Laboratories
Supplier-Nr: A303-614A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Gorilla, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A303-614A-T maps to a region between residue 1 and 50 of human SET Domain and Mariner Transposase Fusion Gene-Containing Protein using the numbering given in entry BAD96454.1 (GeneID 6419).
Format: Antigen Affinity Purified

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