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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F50147-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F50147-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. MELK Contains 1 protein kinase domain that Belongs to... more
Product information "Anti-MELK"
In 1X PBS, pH 7.4, with 0.09% sodium azide. MELK Contains 1 protein kinase domain that Belongs to the Ser/Thr protein kinase family. It phosphorylates ZNF622 and may contribute to its redirection to the nucleus. MELK may also be involved in the inhibition of spliceosome assembly during mitosis. Protein function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. [The UniProt Consortium]
Keywords: | Anti-MELK, Anti-hPK38, Anti-hMELK, Anti-KIAA0175, EC=2.7.11.1, EC=2.7.10.2, Anti-pEg3 kinase, Anti-Protein kinase Eg3, Anti-Protein kinase PK38, Anti-Tyrosine-protein kinase MELK, Anti-Maternal embryonic leucine zipper kinase, MELK Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F50147 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A portion of amino acids 525-554 from the human protein was used as the immunogen for this MELK antibody. |
Format: | Purified |
Database Information
KEGG ID : | K08799 | Matching products |
UniProt ID : | Q14680 | Matching products |
Gene ID | GeneID 9833 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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