Anti-MEK1

Anti-MEK1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-140A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-140A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-140A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP... more
Product information "Anti-MEK1"
Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. [The UniProt Consortium]
Keywords: Anti-MEK1, Anti-MKK1, Anti-MEK 1, Anti-MAP2K1, Anti-MAPKK 1, EC=2.7.12.2, Anti-MAPK/ERK kinase 1, Anti-MAP kinase kinase 1, Anti-ERK activator kinase 1, Anti-Dual specificity mitogen-activated protein kinase kinase 1
Supplier: Bethyl Laboratories
Supplier-Nr: A302-140A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: X. Laevis, Rabbit, Chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by A302-140A-T maps to a region between residue 343 and 393 of human MAPK/ERK kinase 1 (Dual specificity mitogen-activated protein kinase kinase 1) using the numbering given in entry NP_002746.1 (GeneID 5604).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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