Anti-MCM7, clone SPM379

Anti-MCM7, clone SPM379
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3377SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. MCM7 is one of the highly conserved... more
Product information "Anti-MCM7, clone SPM379"
1 mg/ml in 1X PBS, BSA free, sodium azide free. MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Protein function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. [The UniProt Consortium]
Keywords: Anti-MCM7, Anti-CDC47, Anti-P1.1-MCM3, EC=3.6.4.12, Anti-CDC47 homolog, Anti-DNA replication licensing factor MCM7, MCM7 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3377SAF-100UG

Properties

Application: FC, IF, IHC (paraffin), WB
Antibody Type: Monoclonal
Clone: SPM379
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A human full length recombinant protein was used as the immunogen for the MCM7 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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