Anti-MBD2

Anti-MBD2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30151 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Methyl-CpG-binding domain protein 2 is a... more
Product information "Anti-MBD2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene. It is mapped to 18q21.2. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Protein function: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. [The UniProt Consortium]
Keywords: Anti-MBD2, Anti-DMTase, Anti-Demethylase, Anti-Methyl-CpG-binding protein MBD2, Anti-Methyl-CpG-binding domain protein 2, MBD2 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R30151

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Human partial recombinant protein (AA 159-411) was used as the immunogen for this MBD2 antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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