Anti-MATN1 (Matrilin-1, CMP, CRTM)

Matrilin­1, also known as Cartilage Matrix Protein (CMP) is a 50­60kD extracellular matrix protein that belongs to the superfamily of von Willebrand factor A (VWA) containing proteins. It is primarily expressed in cartilage and functions as a bridging component between proteins of the collagenous matrix. Mature human Matrilin­1 contains two VWA domains that flank one EGF­like repeat, followed by a C­terminal coiled coil domain. The Matrilins differ in the number of VWA domains (one or two) and EGF­like repeats (one, three, four, or ten) they contain. Human Matrilin­1 shares 91% aa sequence identity with human and rat Matrilin­1. The coiled coil domain of Matrilin­1 mediates disulfide­linked homo­trimer formation. It can also assemble into hetero­oligomers with Matrilin­2, ­3, and ­4. Applications: Suitable for use in ELISA and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunocytochemistry: 8­25ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.