Anti-MASTL / Microtubule-associated serine/threonine-protein kinase-like

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MASTL antibody detects Microtubule-associated serine/threonine-protein kinase-like, encoded by the MASTL gene. Microtubule-associated serine/threonine-protein kinase-like, also known as Greatwall kinase, is a mitotic kinase that regulates cell cycle progression by controlling phosphatase activity. MASTL antibody provides researchers with a critical reagent for studying mitosis, cell division, and cancer biology.Greatwall kinase functions by phosphorylating proteins such as ENSA and ARPP19, which in turn inhibit the phosphatase PP2A-B55. Research using MASTL antibody has shown that this inhibition is necessary to maintain phosphorylation of mitotic substrates during cell division. By suppressing premature dephosphorylation, MASTL ensures orderly progression through mitosis and faithful chromosome segregation.Studies with MASTL antibody have revealed that depletion of MASTL results in defective chromosome condensation, premature mitotic exit, and genomic instability. These defects highlight the essential role of MASTL in controlling mitotic events. In mouse models, loss of MASTL leads to embryonic lethality, confirming its importance in development.Dysregulation of Microtubule-associated serine/threonine-protein kinase-like has been associated with cancer. Research using MASTL antibody has shown that overexpression drives proliferation and correlates with poor prognosis in breast, lung, and colorectal cancers. Its role in sustaining mitotic kinase activity makes it a potential therapeutic target for anti-cancer therapies focused on disrupting mitotic progression.Beyond cancer, MASTL influences responses to DNA damage. Research using MASTL antibody has demonstrated that the kinase helps coordinate checkpoint recovery and cell cycle re-entry after genotoxic stress. This connection links mitotic regulation to DNA repair pathways and broadens the scope of MASTL function.MASTL antibody is widely applied in western blotting, immunohistochemistry, and kinase assays. Western blotting quantifies expression in proliferating cells, immunohistochemistry highlights localization in tumors, and kinase assays confirm activity on ENSA and ARPP19. These applications make MASTL antibody indispensable for cell cycle and oncology research.By providing validated MASTL antibody reagents, NSJ Bioreagents supports studies into mitotic control, checkpoint signaling, and cancer. Detection of Microtubule-associated serine/threonine-protein kinase-like provides researchers with insight into how kinases regulate cell division and disease.