Anti-MART-1 for IHC / Melan-A, clone MSVA-900M

Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide. MART-1, also known as Melan A or MLANA, is a melanocyte-associated antigen involved in melanosome formation and pigment production and is widely expressed in normal melanocytes and melanocytic tumors. It is recognized as a key antigen associated with melanocytic differentiation and is commonly used as a marker for identifying melanoma and related lesions. In immunohistochemistry, MART-1 is detected as cytoplasmic HRP-DAB brown staining in melanocytes and melanoma cells, providing a clear and reliable pattern for identifying melanocytic lineage in FFPE tissue sections. MART-1 Antibody for IHC is frequently used in studies of melanoma biology and tumor identification.MART-1 antibody, also referred to as Melan A antibody or MLANA antibody in the literature, recognizes a cytoplasmic protein with highly restricted expression in melanocytic cells. This MART-1 Antibody for IHC is optimized for Tissue Microarray (TMA)-based immunohistochemistry, enabling high-throughput evaluation of melanocyte-associated antigen expression across diverse tissue panels. In normal tissue TMAs, staining is limited to melanocytes, while the majority of non-melanocytic tissues remain negative, reinforcing its specificity for melanocytic lineage detection.In cancer tissue microarrays, MART-1 expression is strongly associated with melanoma, where diffuse cytoplasmic staining highlights tumor cells with melanocytic origin. This staining pattern enables clear visualization of tumor cell populations within complex tumor microenvironments and supports differentiation from non-melanocytic malignancies. The absence of staining in most epithelial and mesenchymal tumors further supports its lineage specificity.Tissue Microarray (TMA) analysis allows direct comparison of MART-1 expression across a wide range of normal and cancer tissues under standardized conditions, demonstrating consistent and reproducible staining in melanocytic tumors with minimal background signal. Clone MSVA-900M provides clear and well-defined cytoplasmic staining across TMA cores, supporting its use in melanoma-focused tissue profiling and antigen-based studies. Observed staining patterns are consistent with established MLANA expression profiles and publicly available datasets such as the Human Protein Atlas.This antibody targets MART-1 in research applications requiring reliable immunohistochemical detection of melanoma-associated antigens, making it well suited for studies of melanoma biology, tumor identification, and melanocytic differentiation.This antibody is part of the Melan-A antibody collection, where additional MLANA/MART-1 antibodies for various applications can be explored.This antibody is also part of a broader collection of IHC antibodies validated by tissue microarray analysis, supporting consistent staining across normal and cancer tissues.