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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3532IHC-7ML | 7 ml | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-MAML2, clone MAML2/1302"
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only*. Mastermind-like 2, also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, it interacts with the ankyrin repeats of the Notch proteins (1-4). This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jkappa, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors. Protein function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. [The UniProt Consortium]
Keywords: | Anti-MAML2, Anti-Mam-2, Anti-KIAA1819, Anti-Mastermind-like protein 2, MAML2 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3532IHC |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | MAML2/1302 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A human recombinant full length protein |
Format: | Purified |
Database Information
KEGG ID : | K06061 | Matching products |
UniProt ID : | Q8IZL2 | Matching products |
Gene ID | GeneID 84441 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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