Anti-MAGI2 / Membrane-associated guanylate kinase inverted 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. MAGI2 antibody detects Membrane-associated guanylate kinase inverted 2, a scaffolding protein located at synapses and tight junctions that organizes signaling complexes for cell polarity and neuronal function. MAGI2 belongs to the MAGUK family of adaptor proteins that coordinate receptor clustering, cytoskeletal interactions, and signal transduction. The MAGI2 antibody is used in studies of synaptic signaling, epithelial junction formation, and protein complex organization.MAGI2 is encoded by the MAGI2 gene on human chromosome 7q21.11. The protein is approximately 150 kilodaltons and composed of multiple PDZ, WW, and guanylate kinase-like domains that mediate protein-protein interactions. MAGI2 localizes to postsynaptic densities in neurons and to tight junctions in epithelial cells, where it scaffolds transmembrane receptors such as PTEN, NMDA receptor subunits, and beta-catenin. MAGI2 regulates synaptic plasticity by stabilizing glutamate receptor complexes and maintaining postsynaptic signaling strength. It also anchors PTEN to the plasma membrane, contributing to phosphoinositide signaling and tumor suppression.Defects or deletions in MAGI2 are associated with neurological disorders including autism spectrum disorder and epilepsy, as well as cancers involving disrupted cell polarity. In epithelial cells, MAGI2 supports junctional integrity and signal compartmentalization, preventing uncontrolled growth and maintaining barrier function.As a multifunctional scaffolding protein, MAGI2 integrates membrane signaling with structural organization. NSJ Bioreagents provides a validated MAGI2 antibody optimized for its applications, supporting research into synaptic signaling, polarity regulation, and disease mechanisms involving MAGUK family proteins.