Anti-MAD2L1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA003348.25	25 µl		-		7 - 10 business days*		330.00€
ATA-HPA003348.100	100 µl		-		7 - 10 business days*		463.00€

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Protein function: Component of the spindle-assembly checkpoint that prevents the onset of... more

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Product information "Anti-MAD2L1"

Protein function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:29162720, PubMed:15024386). In the closed conformation (C-MAD2) forms a heterotetrameric complex with MAD1L1 at unattached kinetochores during prometaphase, the complex recruits open conformation molecules of MAD2L1 (O-MAD2) and then promotes the conversion of O-MAD2 to C-MAD2 (PubMed:29162720). Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (PubMed:10700282, PubMed:11804586, PubMed:15024386). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 94% and to rat: 95%

Keywords:	Anti-MAD2, Anti-MAD2L1, Anti-HsMAD2, Anti-MAD2-like protein 1, Anti-Mitotic arrest deficient 2-like protein 1, Anti-Mitotic spindle assembly checkpoint protein MAD2A
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA003348

Properties

Application:	ICC, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: NNVVEQLKDW LYKCSVQKLV VVISNIESGE VLERWQFDIE CDKTAKDDSA PREKSQKAIQ DEIRSVIRQI TATVTFLPLL EVSCSFDLLI YTDKDLVVPE KWEESGPQFI TNSEEVRLRS FTTTIH (ATA-APrEST86433)