Anti-LZTS2 / Leucine zipper putative tumor suppressor 2

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. The LZTS2 antibody targets Leucine zipper putative tumor suppressor 2, a microtubule-associated protein encoded by the LZTS2 gene. Leucine zipper putative tumor suppressor 2 acts as a cell cycle regulator and transcriptional modulator involved in mitosis, cytoskeletal organization, and growth control. It functions as a negative regulator of beta-catenin signaling and participates in centrosome integrity and spindle orientation. The LZTS2 antibody provides a key tool for studying tumor suppression, cytoskeletal regulation, and Wnt signaling dynamics.Leucine zipper putative tumor suppressor 2 contains multiple coiled-coil and leucine zipper motifs that facilitate protein-protein interactions and localization to microtubules and centrosomes. During mitosis, it associates with the spindle apparatus and contributes to chromosome segregation fidelity. The LZTS2 antibody supports localization studies that reveal its role in maintaining mitotic stability and preventing aneuploidy. Loss of LZTS2 disrupts spindle organization and cell division, leading to chromosomal instability that can promote tumorigenesis.As a regulator of Wnt/beta-catenin signaling, Leucine zipper putative tumor suppressor 2 binds beta-catenin and inhibits its nuclear translocation, thereby attenuating transcription of Wnt target genes involved in proliferation. The LZTS2 antibody enables detection of expression changes in response to Wnt pathway activation or tumor progression. Reduced levels of LZTS2 have been documented in prostate, colorectal, and lung cancers, correlating with enhanced beta-catenin activity and increased malignancy.Beyond cancer biology, Leucine zipper putative tumor suppressor 2 contributes to neural development and cytoskeletal regulation in neurons. It stabilizes microtubule structures and promotes axonal outgrowth, suggesting functions in cellular differentiation and morphogenesis. The LZTS2 antibody supports studies into these roles, providing a means to evaluate expression across developing tissues and in response to neurotrophic factors.The LZTS2 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, producing characteristic cytoplasmic and perinuclear staining consistent with microtubule association. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for use in cancer, developmental, and molecular cell biology research. By enabling detailed characterization of Leucine zipper putative tumor suppressor 2 expression and function, the LZTS2 antibody advances understanding of tumor suppression, cell division control, and cytoskeletal organization.