Anti-LYPD1 (Ly6/PLAUR Domain-containing Protein 1, Putative HeLa Tumor Suppressor, PHTS, LYPDC1, PSE

LYPD1 is a 15-20kD member of the Ly6 family of GPI-anchored proteins. It is expressed on postmitotic neurons in multiple locations, performing multiple functions. Two suggested functions include the ability to 1) block cell proliferation, and 2) bind to acetylcholine receptors, promoting their desensitization. Human LYPD1 preproprecursor is 141aa in length. It contains a signal sequence aa1-20, a 97aa mature region aa21-117, and a cleavable prodomain that, when cleaved, generates a GPI-linked form aa118-141. The mature molecule contains one Ly6 domain aa25-107. There are multiple potential isoform variants. One possesses an alternative start site at Met53, a second contains a 21aa substitution for aa1-5, a third shows a 21aa substitution for aa64-141, and a fourth possesses a 29aa substitution for aa65-141. Over aa54-116, human and mouse LYPD1 are identical in aa sequence. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 5-15ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.