Anti-LRGUK / Leucine-rich repeat and guanylate kinase domain-containing protein

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. LRGUK antibody detects Leucine-rich repeat and guanylate kinase domain-containing protein, a testis-specific protein that plays a critical role in spermatogenesis and sperm flagellar assembly. LRGUK acts as a scaffolding protein that connects the axoneme and peri-basal body structures necessary for sperm motility and morphology. The LRGUK antibody is widely used in reproductive biology and developmental studies to examine flagellar biogenesis, male fertility, and cytoskeletal organization.LRGUK is encoded by the LRGUK gene located on human chromosome 7q22.1. The protein is approximately 1,453 amino acids in length and contains multiple leucine-rich repeats and a C-terminal guanylate kinase-like domain that mediates protein-protein interactions. LRGUK localizes to the distal centriole, connecting piece, and midpiece of developing spermatozoa, where it interacts with structural and motor proteins involved in axonemal extension.The LRGUK antibody detects a 165 kilodalton protein by western blot and shows strong localization in elongating spermatids under immunohistochemistry. LRGUK functions as a molecular linker between microtubules and accessory structures such as the mitochondrial sheath, ensuring proper flagellar alignment and motility. Mutations or knockouts of LRGUK in animal models result in immotile sperm with abnormal tail formation, leading to infertility.Beyond the testis, low levels of LRGUK expression have been reported in ciliated epithelial tissues, suggesting additional roles in ciliogenesis. By anchoring structural elements within motile cilia, LRGUK contributes to coordinated movement and fluid transport in the respiratory and reproductive tracts.Because LRGUK serves as a key structural determinant of flagellar integrity and motility, it represents an important marker for studying male reproductive health and cytoskeletal organization. NSJ Bioreagents provides a validated LRGUK antibody optimized for its applications, supporting research into sperm structure, cilia biology, and fertility disorders.